Antibacterial activity of Cinnamomum zeylanicum aqueous extract against Proteus mirabilis isolated from Urinary Tract Infections in Kerbala province
DOI:
https://doi.org/10.59675/P315Keywords:
Proteus mirabilis, urinary tract infections, virulence factors, Cinnamomum zeylanicumAbstract
Proteus mirabilis from urinary tract infections (UTIs) is to be isolated as well as detected in the presented work. Proteus mirabilis resistance to specific antibiotics is being studied, and the antibacterial activity regarding a cold aqueous extract of Cinnamomum zeylanicum against Proteus mirabilis isolated from UTIs is being tested. 150 patients with diuresis for UTIs comprise the study sample. Thus, 12 (8%) of Proteus mirabilis were isolated. The majority of bacterial isolates tested with such antibiotics exhibited resistance to them. The research's findings indicate that the aqueous extract of Cinnamomum zeylanicum contains active components such as tannins, glycosides, saponins, resins, and phenols in varying amounts, as well as the absence of flavones and phenols. Thus, the bacterial isolates have the greatest impact on concentration (75 mg/ml). Therefore, compared with the control factor, which contains sterile distilled water, the concentration (75 mg/ml) had the highest and lowest diameters of 30 mm and 22 mm, respectively; the concentration (50 mg/ml) had the highest and lowest diameters of 28 mm and 18 mm, respectively; the concentration (25 mg/ml) had the highest diameter of 26 mm and the least diameter of inhibition was 16 mm; and lastly, about the concentration (12.5 mg/ml), the highest and lowest diameters were 23 mm and 12 mm, respectively.
The results of the investigation of some virulence factors showed that 59(100%) isolates can form a swarm, 48(81.35%) isolates can produce biofilm, 50(91.52%) isolates can produce hemolysin, and 24(100%) isolates can produce urease enzymes. Proteus mirabilis is one of the pathogens of UTIs.
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